Trifluoroacetic acid → HCID 178487410, compound

Participants

Reaction Steps

Following general procedure A-2, tert-butyl {trans-4-[6-(3-chloro-4-hydroxy-5-methoxyphenyl)-3-(cyclopropanecarbonyl)quinolin-4-ylamino]cyclohexyl}methylcarbamate (0.123 mmol) was reacted with TFA (2 mL) to afford the desired product (28 mg, 47% over two steps) as a yellow solid: 1H NMR (300 MHz, CD3OD+TFA-d) δ 9.35 (s, 1H), 8.49 (s, 1H), 8.30 (d, J=8.7 Hz, 1H), 7.97 (d, J=8.7 Hz, 1H), 7.33 (s, 1H), 7.26 (s, 1H), 4.0 (s, 1H), 3.99 (s, 3H), 2.90-2.81 (m, 3H), 2.47-2.41 (m, 2H), 2.10-1.98 (m, 2H), 1.83-1.64 (m, 3H), 1.37-1.17 (m, 6H); ESI MS m/z 480 [C27H30ClN3O3+H]+; HPLC>99% (AUC), tR=11.15 min.

Provenance & Evidence