Trifluoroacetic acid → HCID 66715244, compound

Participants

Reaction Steps

Following general procedure A-2, tert-butyl 4-[6-(3-chloro-5-fluoro-4-hydroxyphenyl)-3-(cyclopropanecarbonyl)quinolin-4-ylamino]benzylcarbamate (0.127 mmol) was reacted with TFA (2 mL) to afford the desired product (31 mg, 53% over two steps) as a yellow solid: 1H NMR (300 MHz, CD3OD+TFA-d) δ 9.44 (s, 1H), 8.24 (dd, J=8.9, 1.9 Hz, 1H), 8.08-7.96 (m, 2H), 7.69 (d, J=8.4 Hz, 2H), 7.55 (d, J=8.4 Hz, 2H), 7.17-7.06 (m, 1H), 7.06-6.98 (m, 1H), 4.27 (s, 2H), 2.93-2.80 (m, 1H), 1.25-1.11 (m, 4H); ESI MS m/z 462 [C26H21ClFN3O2+H]+; HPLC>99% (AUC), tR=12.22 min.

Provenance & Evidence