Trifluoroacetic acid → HCID 66715213, compound

Participants

Reaction Steps

Following general procedure A-2, tert-butyl 2-{4-[3-(cyclopropanecarbonyl)-6-(3,5-dichloro-4-hydroxyphenyl)quinolin-4-ylamino]phenyl}propan-2-ylcarbamate (0.145 mmol) was TFA (2 mL) to afford the desired product (21 mg, 28% over two steps) as a yellow solid: 1H NMR (500 MHz, CD3OD+TFA-d) δ 9.33 (s, 1H), 8.26 (dd, J=8.8, 1.9 Hz, 1H), 8.19 (s, 1H), 8.05 (d, J=8.8 Hz, 1H), 7.67 (d, J=8.6 Hz, 2H), 7.53 (d, J=8.6 Hz, 2H), 7.43 (s, 2H), 2.82-2.73 (m, 1H), 1.78 (s, 6H), 1.18-1.10 (m, 4H); ESI MS m/z 506 [C28H25Cl2N3O2+H]+; HPLC 98.7% (AUC), tR=11.00 min.

Provenance & Evidence