Hydrochloric Acid → HCID 66715845, compound

Participants

Reaction Steps

To a suspension of {4-[4-(2-aminopropan-2-yl)phenylamino]-6-(3,5-dichloro-4-hydroxyphenyl)quinolin-3-yl}(cyclopropyl)methanone (14 mg, 0.028 mmol) in methanol (5 mL) was added HCl in ether (3 drops, 2 M). The resultant solution was concentrated to obtain the desired product as the hydrochloride salt (13 mg) as a yellow solid: 1H NMR (500 MHz, CD3OD) δ 9.31 (s, 1H), 8.24-8.22 (m, 1H), 8.18 (s, 1H), 8.04 (d, J=8.8 Hz, 1H), 7.65 (d, J=9.0 Hz, 2H), 7.49 (d, J=9.0 Hz, 2H), 7.42 (s, 2H), 2.84-2.75 (m, 1H), 1.78 (s, 6H), 1.18-1.09 (m, 4H); ESI MS m/z 506 [C28H25Cl2N3O2+H]+; HPLC 98.5% (AUC), tR=10.80 min.

Provenance & Evidence