2,6-Dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol → HCID 66716158, compound

Participants

Reaction Steps

Following general procedure F, {6-bromo-4-[3-(2-(4-methylpiperazin-1-yl)ethyl)phenylamino]quinolin-3-yl}(cyclopropyl)methanone (56 mg, 0.110 mmol) was reacted with 2,6-dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (48 mg, 0.165 mmol) to afford the desired product (47 mg, 74%) as a yellow solid: 1H NMR (500 MHz, CD3OD) δ 9.25 (s, 1H), 7.89 (s, 2H), 7.69 (s, 1H), 7.41 (t, J=7.7 Hz, 1H), 7.24 (d, J=7.7 Hz, 1H), 7.13-6.94 (m, 4H), 2.97-2.84 (m, 1H), 2.82-2.72 (m, 2H), 2.66-2.51 (m, 10H), 2.43 (s, 3H), 1.32-1.06 (m, 4H). ESI MS m/z 575 [C32H32C12N4O2+H]+; HPLC 95.1% (AUC), tR=10.37 min.

Provenance & Evidence