反应详情

温度

0 °C

A few drops of concentrated sulfuric acid is added to a stirring solution of 35.0 g of 4-methacrylamidosalicylic acid (prepared according to Example 1) in 350 mL of acetic anhydride at 0° C. The solution is stirred for 60 minutes at 0° C. and then for an additional 6 hours at room temperature. The reaction mixture is then poured into 800 g of cold deionized water. The solid product precipitates from solution, and is collected by filtration. The product is then air dried at room temperature to afford A-4-MASA in quantitative yield.

1. waitfor an additional 6 hours at room temperature
2. additionThe reaction mixture is then poured into 800 g
3. customThe solid product precipitates from solution
4. filtrationis collected by filtration
5. customair dried at room temperature
6. customto afford A-4-MASA in quantitative yield