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1-Methyl-1H-pyrazole-4-boronic acid → cis-2,2,2-trifluoro-1-[6-(1-methyl-1H-pyrazol-4-yl)-2,3,4,4a,9,9a-hexahydro-indeno[2,1-b]pyridin-1-yl]-ethanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Methyl-1H-pyrazole-4-boronic acid | HCID 11263501 | — |
| 反応物 | HCID 58294405 | HCID 58294405 | — |
| 生成物 | cis-2,2,2-trifluoro-1-[6-(1-methyl-1H-pyrazol-4-yl)-2,3,4,4a,9,9a-hexahydro-indeno[2,1-b]pyridin-1-yl]-ethanone | HCID 58294593 | 32% |
反応手順
The title compound is prepared from trifluoro-methanesulfonic acid cis-1-(2,2,2-trifluoro-acetyl)-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridin-6-yl ester and 1-methyl-pyrazol-4-yl-boronic acid following a procedure analogous to that described in Step 2 of Intermediates 17 and 18. Yield: 32% of theory; LC (method 1): tR=3.88 min; Mass spectrum (ESI+): m/z=350 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09120769B2 |
| 出典データセット | uspto-grants-2015_09 |
| ORD ID | ord-3cb67e37845d424ba44665b417d04482 |
| 出典メモ | uspto-grants-2015_09 |