Ammonia → HCID 178513515, compound

HRID 2272055Notes

Reaction equation

HRID 2272055 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([N:12]3[C@@H:21]4[C@@H:16]([C:17]5[CH:25]=[CH:24][C:23]([C:26]([OH:28])=O)=[CH:22][C:18]=5[CH2:19][CH2:20]4)[CH2:15][CH2:14][CH2:13]3)=[O:11])=[CH:9][C:4]=2[N:3]=[CH:2]1.[NH3:29]>>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([N:12]3[C@@H:21]4[C@@H:16]([C:17]5[CH:25]=[CH:24][C:23]([C:26]([NH2:29])=[O:28])=[CH:22][C:18]=5[CH2:19][CH2:20]4)[CH2:15][CH2:14][CH2:13]3)=[O:11])=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 178524091HCID 178524091, compound

Product 1

HCID 178513515HCID 178513515, compoundYield 58%

Procedure

The title compound is prepared from cis-4-(1H-benzoimidazole-5-carbonyl)-1,2,3,4,4a,5,6,10b-octahydro-benzo[f]quinoline-8-carboxylic acid and ammonia (28% in water) following a procedure analogous to that described in Example 1. Yield: 58% of theory; LC (method 1): tR=1.78 min; Mass spectrum (ESI+): m/z=375 [M+H]+.

Sources & evidence

ORD record
ord-48ddd4f21eaa43fabedd0b99e1eaa227
Source dataset
uspto-grants-2015_09
Patent number
US09120769B2

Reaction notes

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