HCID 67198600, compound → HCID 178435239, compound

HRID 2272115Notes

Reaction equation

HRID 2272115 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([OH:12])=O)=[CH:9][C:4]=2[N:3]=[CH:2]1.[CH2:13]([C@:15]12[C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=3[CH2:22][CH2:21][C@@H:20]1[NH:19][CH2:18][CH2:17][CH2:16]2)[CH3:14]>C(Cl)Cl.CO>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([N:19]3[C@@H:20]4[C@:15]([CH2:13][CH3:14])([C:24]5[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=5[CH2:22][CH2:21]4)[CH2:16][CH2:17][CH2:18]3)=[O:12])=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 67198600HCID 67198600, compoundHCID 178524171HCID 178524171, compound

Product 1

HCID 178435239HCID 178435239, compoundYield 44%

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound is prepared from 1H-benzoimidazole-5-carboxylic acid and trans-10b-ethyl-1,2,3,4,4a,5,6,10b-octahydro-benzo[f]quinoline following a procedure analogous to that described in Example 1. Yield: 44% of theory; TLC: rf=0.42 (silica gel, CH2Cl2/MeOH/32% aqueous NH3 90:10:1); Mass spectrum (ESI+): m/z=360 [M+H]+.

Sources & evidence

ORD record
ord-f896be63ee324a0895f43ea66ee516c7
Source dataset
uspto-grants-2015_09
Patent number
US09120769B2

Reaction notes

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