HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Oxo-1,2-dihydroquinoxaline-6-carboxylic acid → 6-(cis-2,3,4,4a,9,9a-Hexahydro-indeno[2,1-b]pyridine-1-carbonyl)-1H-quinoxalin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Oxo-1,2-dihydroquinoxaline-6-carboxylic acid | HCID 4749962 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | cis-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridine | HCID 58123900 | — |
| Product | 6-(cis-2,3,4,4a,9,9a-Hexahydro-indeno[2,1-b]pyridine-1-carbonyl)-1H-quinoxalin-2-one | HCID 67224239 | 45% |
Reaction Steps
The title compound is prepared from 2-oxo-1,2-dihydro-quinoxaline-6-carboxylic acid and cis-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridine following a procedure analogous to that described in Example 1 [2-(7-aza-1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate is used]. Yield: 45% of theory; LC (method 4): tR=1.89 min; Mass spectrum (ESI+): m/z=346 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09120769B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-62ea121e8d0c41f0961a08389be890a4 |
| Source note | uspto-grants-2015_09 |