Trifluoroacetic acid → HCID 10367176, compound

Participants

Reaction Conditions

Reaction Steps

213 mg of 1-[(benzyloxycarbonyl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-[(R)-3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-xanthine in 2 ml methylene chloride are combined with 1 ml of trifluoroacetic acid and the reaction mixture is shaken for 20 minutes at 30° C. For working up it is made alkaline with 15 ml of 1 N sodium hydroxide solution and the organic phase is separated off. The aqueous phase is extracted with methylene chloride and the combined organic phases are evaporated down. The flask residue is purified through a silica gel column with methylene chloride/methanol (100:0 to 70:30) as eluant.

Provenance & Evidence