Ethyl 2-(oxetan-3-ylidene)propanoate → Ethyl 2-(oxetan-3-yl)propanoate

HRID 2272265ノート

反応式

HRID 2272265 の反応式
[O:1]1[CH2:4][C:3](=[C:5]([CH3:11])[C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH2:2]1>CCO.[Pd]>[O:1]1[CH2:2][CH:3]([CH:5]([CH3:11])[C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH2:4]1

参加物

4

反応物 1

HCID 86698951Ethyl 2-(oxetan-3-ylidene)propanoate

生成物 1

HCID 86698952Ethyl 2-(oxetan-3-yl)propanoate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To a solution of (i) (151 mg, 0.97 mmol) in EtOH (54 mL) was added 10% Pd/C (50 mg, 0.05 mmol). The reaction was degassed and purged with hydrogen at balloon pressure (×3) then stirred under hydrogen at RT for 16 h. The reaction mixture was filtered and the residue washed with acetonitrile (10 mL). The combined organics were concentrated in vacuo and the residue, (ii) (148 mg), was used without further purification.

後処理

  1. customThe reaction was degassed
  2. custompurged with hydrogen at balloon pressure (×3)
  3. filtrationThe reaction mixture was filtered
  4. washthe residue washed with acetonitrile (10 mL)
  5. concentrationThe combined organics were concentrated in vacuo
  6. customthe residue, (ii) (148 mg), was used without further purification

出典と根拠

ORDレコード
ord-bad7372396a34307b35d28603db1a6d6
出典データセット
uspto-grants-2015_09
特許番号
US09120775B2

反応ノート

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