HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S)-2,5-Dihydro-2-isopropyl-3,6-dimethoxypyrazine → Pyrazine, 2,5-dihydro-3,6-dimethoxy-2-(1-methylethyl)-5-[(2,4,5-trifluorophenyl)methyl]-, (2S,5R)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S)-2,5-Dihydro-2-isopropyl-3,6-dimethoxypyrazine | HCID 736065 | — |
| Reactant | 2,4,5-Trifluorobenzyl Bromide | HCID 2777057 | — |
| Product | Pyrazine, 2,5-dihydro-3,6-dimethoxy-2-(1-methylethyl)-5-[(2,4,5-trifluorophenyl)methyl]-, (2S,5R)- | HCID 11290377 | 62.7% |
Reaction Steps
The title compound (3.81 g) was prepared from 3.42 g (18.5 mmol) of (2S)-2,5-dihydro-3,6-dimethoxy-2-isopropylpyrazine and 5 g (22.3 mmol) of 2,4,5-trifluorobenzyl bromide using the procedure described for Intermediate 2, Step A.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07560455B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-de9bda9894da45f6b0b237126ed87194 |
| Source note | uspto-grants-2009_07 |