Methanol → HCID 118037562, compound

Participants

Reaction Steps

A mixture of tert-butyl 4-(4-bromo-2-oxopyridin-1(2H)-yl)piperidine-1-carboxylate (14.7 g), triethylamine (11.5 mL), methanol (50 mL), 1,1′-bis(diphenylphosphino)ferrocene-palladium(II) dichloride (3.01 g), and DMF (137 mL) was stirred at 80 C for 4 hours in a carbon monooxide atmosphere of 0.3 MPa. Water was added to the reaction mixture, followed by extraction with ethyl acetate twice. The obtained organic layer was washed with saturated saline twice and dried over anhydrous magnesium sulfate, and then, the solvent was distilled off under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate) and silica gel column chromatography (NH, hexane/ethyl acetate) to obtain the title compound (8.32 g).

Provenance & Evidence