反应详情

Manganese dioxide (16.6 g) was added to a toluene (80 mL) solution of (2-cyclopropyl-4′-fluoro-5-isopropoxybiphenyl-4-yl)methanol (5.75 g), and the mixture was stirred at 60 C for 1 hour in a nitrogen atmosphere. The reaction mixture was filtered, and then, the solvent was distilled off under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate) to obtain the title compound (4.54 g).

1. filtrationThe reaction mixture was filtered
2. distillationthe solvent was distilled off under reduced pressure
3. customThe obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate)