Sodium Hydroxide → HCID 118038010, compound

Participants

Reaction Steps

A 2 M aqueous sodium hydroxide solution (3 mL) was added to an ethanol (8 mL) solution of methyl 1-(1-(4,5-dicyclopropyl-2-isopropoxybenzyl)piperidin-4-yl)-2-oxo-1,2-dihydropyridine-4-carboxylate (426 mg), and the mixture was stirred at 90 C for 2 hours in a nitrogen atmosphere. The solvent in the reaction mixture was distilled off under reduced pressure. The obtained residue was dissolved in water, and the solution was neutralized with 2 M hydrochloric acid. The resulting solid was collected by filtration and dissolved in ethyl acetate and THF. The solvent in the obtained solution was distilled off under reduced pressure. The obtained residue was crystallized (ethyl acetate/hexane) and recrystallized (ethanol/hexane) to obtain the title compound (286 mg).

Provenance & Evidence