Sodium sulfate decahydrate → HCID 118037534, compound

Participants

Reaction Steps

Diisobutylaluminum hydride (1.5 M toluene solution, 16.3 mL) was added at 0 C to a THF (30 mL) solution of methyl 2-chloro-6-cyclopropyl-2′,4′-difluoro-3-isopropoxybiphenyl-4-carboxylate (3.10 g), and then, the mixture was stirred at 0 C for 20 minutes in a nitrogen atmosphere. Sodium sulfate decahydrate was added to the reaction mixture, and the mixture was stirred for 1 hour. After filtration, the solvent was distilled off under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate) to obtain the title compound (2.18 g).

Provenance & Evidence