Sodium Hydroxide → HCID 118037647, compound

Participants

Reaction Steps

A 2 M aqueous sodium hydroxide solution (2 mL) was added to an ethanol (8 mL) solution of methyl 1-(1-((2-chloro-6-cyclopropyl-2′,4′-difluoro-3-isopropoxybiphenyl-4-yl)methyl)piperidin-4-yl)-2-oxo-1,2-dihydropyridine-4-carboxylate (590 mg), and the mixture was stirred at 80 C for 4 hours in a nitrogen atmosphere. The reaction mixture was concentrated to dryness under reduced pressure. The obtained residue was dissolved in water, and the solution was neutralized with 2 M hydrochloric acid. The resulting solid was collected by filtration and recrystallized (DMSO/ethanol) to obtain the title compound (157 mg).

Provenance & Evidence