Methanol → HCID 118037920, compound

Participants

Reaction Steps

A mixture of tert-butyl 4-(3-ethyl-2-oxo-4-(((trifluoromethyl)sulfonyl)oxy)pyridin-1(2H)-yl)piperidine-1-carboxylate (1.14 g), triethylamine (0.699 mL), methanol (3.05 mL), 1,1′-bis(diphenylphosphino)ferrocene-palladium(II) dichloride (0.184 g), and DMF (12.5 mL) was stirred at 90 C for 4 hours in a carbon monooxide atmosphere of 0.5 MPa. Water was added to the reaction mixture, followed by extraction with ethyl acetate twice. The obtained organic layer was washed with saturated saline twice and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The obtained residue was purified by silica gel column chromatography (NH, hexane/ethyl acetate) to obtain the title compound (0.798 g).

Provenance & Evidence