HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 6-Bromo-2,4'-difluoro-3-hydroxybiphenyl 4 carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Dibromoisocyanuric acid | HCID 192912 | — |
| Reactant | 2,4'-Difluoro-3-hydroxy-[1,1'-biphenyl]-4-carbaldehyde | HCID 90423951 | — |
| Solvent | Water | HCID 962 | — |
| Product | 6-Bromo-2,4'-difluoro-3-hydroxybiphenyl 4 carbaldehyde | HCID 90423104 | 181.8% |
Reaction Steps
Dibromoisocyanuric acid (8.87 g) was added at room temperature to a DMF (75 mL) solution of 2,4′-difluoro-3-hydroxybiphenyl-4-carbaldehyde (12.7 g), and the mixture was stirred at room temperature for 30 minutes. Water (50 mL) was added dropwise to the reaction mixture, and the mixture was stirred at room temperature for 1 hour. The resulting solid was collected by filtration, then washed with DMF-water, and dried to obtain the title compound (17.6 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09120777B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-8b6d88c2c2304973872962e6e7360369 |
| Source note | uspto-grants-2015_09 |