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Phenylalanine amide → Tert-butyl 3-benzyl-2-oxo-1,4,8-triazaspiro[4,5]decane-8-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenylalanine amide | HCID 445694 | — |
| 反応物 | tert-Butyl 2-oxopiperidine-1-carboxylate | HCID 7577838 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Tert-butyl 3-benzyl-2-oxo-1,4,8-triazaspiro[4,5]decane-8-carboxylate | HCID 68839899 | — |
反応手順
N-tert-Butyloxycarbonylpiperidone (6.0 g, 29.8 mmol) was added to a solution of phenylalaninamide (4.9 g, 29.8 mmol) in dry EtOH (20 ml) and the mixture was heated under reflux for 2.5 h. The solvent was removed by distillation, and the tert-butyl 3-benzyl-2-oxo-1,4,8-triazaspiro[4,5]decane-8-carboxylate (10.8 g) was used in the following reaction without further workup.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07560468B2 |
| 出典データセット | uspto-grants-2009_07 |
| ORD ID | ord-a2d1db906421471b89f7d544cf88dcf8 |
| 出典メモ | uspto-grants-2009_07 |