Cesium carbonate → HCID 86700750, compound

Participants

Reaction Conditions

Reaction Steps

A solution of compound (1a) (200 mg), copper(I) iodide (50 mg), cesium carbonate (430 mg), 4-bromo-2-(tert-butylamino)benzonitrile (250 mg), and N,N-dimethylethane-1,2-diamine (0.11 mL) in 1,4-dioxane (3.3 mL) was stirred overnight under heating at 150° C. After completion of the reaction, the reaction solution was allowed to standing still for cooling, filtered, and the filtrate was partitioned between ethyl acetate and water. The organic layer was washed with saturated brine and dried by the addition of anhydrous sodium sulfate. After removal of the solvent by evaporation, the residue was purified by neutral silica gel column chromatography (chloroform/ethyl acetate/methanol) to obtain compound (1b) (146 mg, yield 47%) as a white foamy substance.

Provenance & Evidence