Ammonium Chloride → HCID 86700755, compound

Participants

Reaction Conditions

Reaction Steps

A solution of compound (10a) (470 mg), iron powder (584 mg) and ammonium chloride (470 mg) in THF (3.5 mL), methanol (3.5 mL) and water (3.5 mL) was stirred under heating at 80° C. for 2 hours. After completion of the reaction, the reaction solution was allowed to standing still for cooling, filtered, and the filtrate was concentrated. Water was added to the obtained residue to precipitate a solid, which was collected by filtration and dried to obtain compound (10b) (390 mg, yield 89%) as a milky white solid.

Provenance & Evidence