Hydrogen Peroxide → HCID 86700757, compound

Participants

Reaction Steps

To a solution of compound (20a) (50 mg) in DMSO (0.5 mL) were added 4N aqueous sodium hydroxide solution (56 μL) and aqueous hydrogen peroxide solution (25 μL), and the mixture was stirred at room temperature for 10 minutes. After completion of the reaction, an aqueous ammonium chloride solution was added to the reaction solution, and then the mixture was partitioned with ethyl acetate. The organic layer was washed with saturated brine and dried by the addition of anhydrous sodium sulfate. After removal of the solvent by evaporation, the residue was subjected to slurry washing with acetonitrile. The precipitated solid was collected by filtration and dried to obtain compound (24) (33 mg, yield 63%) as a milky white solid.

Provenance & Evidence