HCID 86700761, compound → HCID 86700760, compound

Participants

Reaction Conditions

Reaction Steps

Methyltriphenylphosphonium bromide (1.14 g) was suspended in tetrahydrofuran (6.0 mL), and to this solution was added n-butyl lithium (in 2.64 M hexane solution of 1.16 mL) at −78° C. The mixture was stirred at 0° C. for 1 hour and then a solution of compound (48a) (0.91 g) in tetrahydrofuran (2.0 mL) was added thereto, followed by stirring at room temperature for 1 hour. The reaction solution was partitioned with ethyl acetate and water, and the organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, and the solvent was removed by evaporation. The residue was purified by neutral silica gel column chromatography (hexane/ethyl acetate) to obtain compound (48b) (0.864 g, 95%) as a colorless oily substance.

Provenance & Evidence