Hydrochloric Acid → 5-(Benzyl(4-cyanophenyl)amino)-3-methyl-5-oxopentanoic acid

Participants

Reaction Steps

A solution of the compound obtained in Step 2 (80.0 mg, 0.23 mmol) and 1N aqueous sodium hydroxide solution (1 mL, 1.00 mmol) in methanol (2 mL) and THF (2 mL) was stirred at room temperature for 14 hr. The reaction solution was neutralized with 1N hydrochloric acid, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, and dried, and the solvent was evaporated under reduced pressure to give crude 5-(benzyl(4-cyanophenyl)amino)-3-methyl-5-oxopentanoic acid (74.2 mg, 0.221 mmol, 97%) as a white powder.

Provenance & Evidence