3-Amino-9-ethylcarbazole → HCID 71538152, compound

Participants

Reaction Steps

To a solution of the compound obtained in Step 1 (300 mg, 1.07 mmol), 3-amino-9-ethylcarbazole (270 mg, 1.28 mmol) and DIEA (0.560 mL, 3.21 mmol) in DMF (6 mL) was added HATU (610 mg, 1.60 mmol), and the mixture was stirred at room temperature for 14 hr. To the reaction solution was added water, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, and dried, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (solvent gradient; 5 to 75% ethyl acetate/hexane) to give the title compound (225 mg, 0.476 mmol, 44.5%) as a white powder.

Provenance & Evidence