3-Methylglutaric anhydride → HCID 86729730, compound

Participants

Reaction Steps

A solution of 4-amino-2-(trifluoromethyl)benzonitrile (500 mg, 2.69 mmol) and 4-methyldihydro-2H-pyran-2,6(3H)-dione (344 mg, 2.69 mmol) in THF (15 mL) was stirred at 90° C. for 14 hr. The reaction solution was concentrated to give 5-(4-cyano-3-(trifluoromethyl)phenylamino)-3-methyl-5-oxopentanoic acid (964 mg, 3.07 mmol, 114%) as a crude product.

Provenance & Evidence