Water → HCID 86729747, compound

Participants

Reaction Steps

To a solution of the compound obtained in Step 1 (150 mg, 0.48 mmol) and 2-chloro-4-fluorobenzonitrile (75 mg, 0.48 mmol) in THF (6 mL) was added potassium t-butoxide (136 mg, 1.21 mmol), and the mixture was stirred at room temperature for 3 days. Water was poured into the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, and dried, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (solvent gradient; 5 to 85% ethyl acetate/hexane) to give the title compound (79 mg, 0.178 mmol, 36.8%) as a white powder.

Provenance & Evidence