Water → HCID 86729766, compound

Participants

Reaction Steps

To a solution of the compound obtained in Step 1 (1.0 g, 2.96 mmol) in THF (10 mL) was added a THF (5.91 mL, 5.91 mmol) solution of 1M borane-tetrahydrofuran complex at room temperature, and the mixture was stirred for 14 hr. To the reaction mixture was added water, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, and dried, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (solvent gradient; 10 to 100% ethyl acetate/hexane) to give N-(9-ethyl-9H-carbazol-3-yl)-5-hydroxy-3-methylpentanamide (0.514 g, 1.586 mmol, 53.7%) as a colorless powder.

Provenance & Evidence