1-Isocyanato-4-methoxybenzene → HCID 86610062, compound

HRID 227261Notes

Reaction equation

HRID 227261 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]=[C:10]=[O:11])=[CH:5][CH:4]=1.[CH2:12]([N:19]1[C:23]2([CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)[NH:22][CH:21]([CH2:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:20]1=[O:36])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:10]([N:26]2[CH2:27][CH2:28][C:23]3([N:19]([CH2:12][C:13]4[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=4)[C:20](=[O:36])[CH:21]([CH2:29][C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=4)[NH:22]3)[CH2:24][CH2:25]2)=[O:11])=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 794431-Isocyanato-4-methoxybenzeneHCID 688379421,3-Dibenzyl-1,4,8-triazaspiro[4,5]decan-2-one

Product 1

HCID 86610062HCID 86610062, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

4-Methoxyphenyl isocyanate (221 mg, 1.49 mmol) was added to a solution of 1,3-di-benzyl-1,4,8-triazaspiro[4,5]decan-2-one (499 mg, 1.49 mmol) in toluene (12.3 ml) with stirring under a blanket of nitrogen at RT. The reaction mixture was stirred at 115° C. for 4 h. After removal of the solvent, the desired product 11,3-dibenzyl-2-oxo-1,4,8-triazaspiro[4,5]decane-8-carboxylic acid (4-methoxyphenyl)amide was obtained by means of preparative HPLC.

Workup

  1. stirringThe reaction mixture was stirred at 115° C. for 4 h
  2. customAfter removal of the solvent

Sources & evidence

ORD record
ord-32964b08ca594349935029da9a38871c
Source dataset
uspto-grants-2009_07
Patent number
US07560468B2

Reaction notes

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