3-Amino-9-ethylcarbazole → HCID 86729770, compound

Participants

Reaction Steps

A solution of the compound obtained in Step 1 (1.2 g, 3.50 mmol), 9-ethyl-9H-carbazol-3-ylamine (0.736 g, 3.50 mmol), HATU (1.464 g, 3.85 mmol) and TEA (0.537 mL, 3.85 mmol) in DMF (10 mL) was stirred at room temperature for 3 hr. To the reaction mixture was added brine at room temperature, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, and dried, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (solvent gradient; 10 to 50% ethyl acetate/hexane), and crystallized from ethyl acetate to give the title compound (0.187 g, 0.350 mmol, 9.98%) as white crystals.

Provenance & Evidence