Ethyl Acetate → HCID 86729785, compound

Participants

Reaction Steps

To a solution of N-(9-ethyl-9H-carbazol-3-yl)-5-hydroxy-3-methylpentanamine (0.40 g, 1.23 mmol) in DMF (10.0 mL) was added potassium-t-butoxide (0.304 g, 2.71 mmol) under argon atmosphere. The mixture was stirred at room temperature for 15 min, and 4-fluorophthalonitrile (0.270 g, 1.85 mmol) was added thereto. The reaction solution was stirred at room temperature for 14 hr, and ethyl acetate (100 mL) was added thereto. The organic layer was washed with cold water (2×25 mL) and saturated brine (2×25 mL), and dried, and the solvent was evaporated under reduced pressure. The obtained residue was purified by preparative HPLC to give the title compound (0.285 g, 51%) as a white powder.

Provenance & Evidence