HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Fluoroindole → 6-fluoro-3-(piperidin-4-yl)-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Fluoroindole | HCID 351278 | — |
| Reactant | Piperonylamine | HCID 2723901 | — |
| Catalyst | Adams' catalyst | HCID 345198 | — |
| Product | 6-fluoro-3-(piperidin-4-yl)-1H-indole | HCID 11096077 | 51% |
Reaction Steps
This compound was prepared following the procedure described in Example 1 (steps A and B) starting with 1 g (7.4 mmol) of 6-fluoroindol and 2.84 g (18.5 mmol) of 4-piperidone monohydrate hydrochloride. In this case, the hydrogenation step took place for 1 hour at 2 bar and the catalyst used was platinum (IV) oxide. 0.640 g (51% yield) of 6-fluoro-3-piperidin-4-yl-1H-indole were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07560471B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-3b9afbbc53af465c8404096c86d60d23 |
| Source note | uspto-grants-2009_07 |