HRID2272753

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1cc2nccc(Oc3ccc(N)cc3C(C)C)c2cc1OC

HCID89580638

未命名化合物

结构：CCn1nc(C(=O)O)c(=O)n(-c2ccc(F)cc2)c1=O

HCID89581572

未命名化合物

PRODUCTS

生成物

结构：CCn1nc(C(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)c(C(C)C)c2)c(=O)n(-c2ccc(F)cc2)c1=O

HCID90452720

未命名化合物

PROCEDURE

实验过程

This compound was synthesized using 4-(6,7-dimethoxy-quinolin-4-yloxy)-3-isopropyl-phenylamine and 2-ethyl-4-(4-fluorophenyl)-3,5-dioxo-2,3,4,5-tetrahydro-[1,2,4]triazine-6-carboxylic acid using the procedure for example 1. mp=155-156° C.; LCMS m/z=600 (M+1); 1H NMR (CDCl3) δ: 10.78 (s, 1H), 8.47 (d, 1H, J=5.5 Hz). 7.72 (s, 1H), 7.66 (d, 1H, J=8 Hz), 7.59 (s, 1H), 7.43 (s, 1H), 7.31-7.24 (m, 3H), 7.07 (d, 1H, J=9 Hz), 6.35 (d, 1H, J=6 Hz), 4.34 (q, 2H, J=7.3 Hz), 4.05 (s, 6H), 3.11 (m, 1H), 1.58 (t, 3H, J=6 Hz), 1.19 (d, 6H, J=7 Hz).

WORKUP

后处理

customThis compound was synthesized

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-49486f9010c448f7a50934eccb3c2b4e
来源数据集: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09120778B2
来源说明: uspto-grants-2015_09

反应 SMILES

[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][C:16]1[CH:21]=[CH:20][C:19]([NH2:22])=[CH:18][C:17]=1[CH:23]([CH3:25])[CH3:24].[CH2:26]([N:28]1[C:33](=[O:34])[N:32]([C:35]2[CH:40]=[CH:39][C:38]([F:41])=[CH:37][CH:36]=2)[C:31](=[O:42])[C:30]([C:43](O)=[O:44])=[N:29]1)[CH3:27]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][C:16]1[CH:21]=[CH:20][C:19]([NH:22][C:43]([C:30]2[C:31](=[O:42])[N:32]([C:35]3[CH:40]=[CH:39][C:38]([F:41])=[CH:37][CH:36]=3)[C:33](=[O:34])[N:28]([CH2:26][CH3:27])[N:29]=2)=[O:44])=[CH:18][C:17]=1[CH:23]([CH3:25])[CH3:24]