HCID 89580730, compound → HCID 90452722, compound

HRID 2272755Notes

Reaction equation

HRID 2272755 reaction equation
[CH3:1][O:2][C:3]1[C:12]([O:13][CH3:14])=[CH:11][CH:10]=[C:9]2[C:4]=1[C:5]([O:15][C:16]1[CH:21]=[CH:20][C:19]([NH2:22])=[CH:18][CH:17]=1)=[CH:6][CH:7]=[N:8]2.[CH2:23]([N:25]1[CH:30]=[C:29]([C:31](O)=[O:32])[C:28](=[O:34])[N:27]([C:35]2[CH:40]=[CH:39][C:38]([F:41])=[CH:37][CH:36]=2)[C:26]1=[O:42])[CH3:24]>>[CH3:1][O:2][C:3]1[C:12]([O:13][CH3:14])=[CH:11][CH:10]=[C:9]2[C:4]=1[C:5]([O:15][C:16]1[CH:17]=[CH:18][C:19]([NH:22][C:31]([C:29]3[C:28](=[O:34])[N:27]([C:35]4[CH:40]=[CH:39][C:38]([F:41])=[CH:37][CH:36]=4)[C:26](=[O:42])[N:25]([CH2:23][CH3:24])[CH:30]=3)=[O:32])=[CH:20][CH:21]=1)=[CH:6][CH:7]=[N:8]2

Participants

3

Reactant 2

HCID 89580730HCID 89580730, compoundHCID 895826181-Ethyl-3-(4-fluorophenyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid

Product 1

HCID 90452722HCID 90452722, compound

Procedure

This compound was synthesized using 4-(5,6-dimethoxy-quinolin-4-yloxy)-phenylamine and 1-ethyl-3-(4-fluorophenyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid using the procedure for example 1. mp>250° C.; LCMS m/z=557 (M+1); 1H NMR (DMSO) δ: 10.92 (s, 1H), 8.86 (s, 1H), 8.48 (m, 1H), 7.79 (m, 2H), 7.49 (s, 1H), 7.35-7.42 (m, 5H), 7.24-7.27 (m, 2H), 6.49 (m, 1H), 4.00 (m, 2H), 3.94 (s, 3H), 3.92 (s, 3H), 1.29 (m, 3H).

Workup

  1. customThis compound was synthesized

Sources & evidence

ORD record
ord-9b7383c322fb486d92e66e3420222563
Source dataset
uspto-grants-2015_09
Patent number
US09120778B2

Reaction notes

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