反应详情

(S)-omeprazole (1.0 g, 2.9 mmol) was dissolved in acetonitrile (10 ml). (R)-1-cyclohexyl ethyl amine (0.83 ml, 5.7 mmol) was added to the solution whereupon a white solid precipitated. After 45 minutes acetonitril (10 ml) was added to the thick reaction mass and stirring was continued for 45 minutes. The precipitate was filtered off, washed with acetonitrile, and dried. 0.5 g of the title compound was obtained.

1. customprecipitated
2. additionAfter 45 minutes acetonitril (10 ml) was added to the thick reaction mass
3. filtrationThe precipitate was filtered off
4. washwashed with acetonitrile
5. customdried