Lithium Hydroxide → HCID 57751788, compound

Participants

Reaction Steps

To a solution of substrate 11 (68 mg, 0.130 mmol) in THF:MeOH:H2O (1.5:1:1 mL) was added lithium hydroxide (27 mg, 0.65 mmol) at room temperature. The reaction mixture was stirred for 1 hour and neutralized with saturated ammonium chloride solution, extracted with ethyl acetate (3×5 mL), washed with brine. The combined organic layers were dried over anhydrous Na2SO4 and concentrated under vacuum. The residue was purified by column chromatography on silica using dichloromethane and methanol (96:4) as eluent to give diastereomers 16a (30 mg, 47%) and 16b (20 mg, 31%), both as white amorphous solids.

Provenance & Evidence