反应详情

To a flask containing 630 mg (3.1 mmol) of DCC (dicyclohexylcarbodiimide) was added 3 ml of methylene chloride and with stirring a solution of 625 mg (3.1 mmol) of 3,4-dichlorophenyl acetic acid in 5 ml of methylene chloride was added dropwise resulting in the formation of a precipitate. The reaction mixture was stirred for 5 minutes, and to it was added 550 mg (3.05 mmol) of 1-(3-pyridyl)-2-methylaminoethanol in 6 ml of methylene chloride, it was stirred further for 1 hour at 20° C. A precipitate formed was filtered off, and the resulting solution was evaporated. The evaporated filtrate was purified by column chromatography on silica gel (silica gel 60, mobile phase: CHCl3:CH3OH=10:0.5). This yields 0.56 g (50%) of 1-(3-pyridyl)-2-(N-(2-(3,4-dichlorophenyl)acetyl)-N-propylamino)ethanol in the form the oil (molecular weight: 367.278, gross formula: C18H20N2O2Cl2).

1. additionwas added dropwise
2. customresulting in the formation of a precipitate
3. stirringwas stirred further for 1 hour at 20° C
4. customA precipitate formed
5. filtrationwas filtered off
6. customthe resulting solution was evaporated
7. customThe evaporated filtrate was purified by column chromatography on silica gel (silica gel 60, mobile phase: CHCl3:CH3OH=10:0.5)