Diisobutylaluminum hydride → HCID 118129967, compound

Participants

Reaction Steps

To a solution of methyl 2-bromo-[1,2,4]triazolo[1,5-a]pyridine-6-carboxylate (3.0 g, 11.7 mmol) in DCM, is added DIBAL-H (3 equivalents) drop wise at −78° C. and the reaction mixture is warmed to room temperature and stirred for 1 hour. The reaction mixture is quenched with saturated ammonium chloride solution (20 mL) and extracted with DCM (2×50 mL). The combined organic extracts are dried over sodium sulphate, and evaporated. The crude material is triturated with n-pentane to give the title compound as a yellow solid (1.5 g, 57.6%). LCMS m/z 171 (M+H)+.

Provenance & Evidence