Sodium Hydroxide → HCID 118129974, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (S)-3-(4-{2-[4-(3-methanesulfonyl-propoxy)-2,6-dimethyl-phenyl]-[1,2,4]triazolo[1,5-a]pyridin-6-ylmethoxy}-phenyl)-hex-4-ynoic acid ethyl ester (0.145 g, 0.238 mmol) in EtOH (5 mL) is added 5 N NaOH solution (0.14 mL, 0.715 mmol) at room temperature and the reaction mixture is heated at 50° C. for 30 minutes. The reaction mixture is evaporated and the residue is dissolved in water (5 mL), washed with ether (2×5 mL), and acidified with aqueous citric acid solution (pH-6) at 0° C. The precipitate solid is filtered and dried to give the title compound as an off-white solid (0.075 g, 55%). LCMS m/z 576 [M+H]+.

Provenance & Evidence