2-(4-Chlorophenyl)ethylamine → HCID 89480012, compound

HRID 2272858Notes

Reaction equation

HRID 2272858 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][NH2:10])=[CH:4][CH:3]=1.[CH3:11][C:12]1([CH3:22])[O:16][C:15](=[CH:17][C:18](O)=[O:19])[C:14](=[O:21])[O:13]1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][NH:10][C:18](=[O:19])[CH:17]=[C:15]2[C:14](=[O:21])[O:13][C:12]([CH3:11])([CH3:22])[O:16]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 674302-(4-Chlorophenyl)ethylamineHCID 68860642(2,2-Dimethyl-5-oxo-[1,3]dioxolan-4-ylidene)-acetic acid

Product 1

HCID 89480012HCID 89480012, compound

Procedure

By appropriate application of method described in Intermediate 7, 2-(4-chlorophenyl)ethylamine (0.27 mL, 1.9 mmol) and 2-(2,2-dimethyl-5-oxo-1,3-dioxolan-4-ylidene)acetic acid (365 mg, 2.12 mmol) were converted to Example 241A (190 mg, 32%) as a white solid. HPLC/MS (Method L) RT=1.78 min, [M+1]+ 310.0.

Sources & evidence

ORD record
ord-089288722a8b4e8ab2e91542a9db7b8f
Source dataset
uspto-grants-2015_09
Patent number
US09120794B2

Reaction notes

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