反应详情

温度

70 °C

To a solution of 12 g of 4-anilinophenol (64.7 mmol) in 200 mL of acetonitrile there are added at ambient temperature 6.7 g of imidazole (97.05 mmol) and 11.7 g of tert-butyl(chloro)dimethylsilane (77.64 mmol). The whole is stirred at 70° C. for 4 hours. Then the reaction mixture is poured onto water and extracted with ether. The organic phase is subsequently dried over magnesium sulphate and then filtered and evaporated to dryness. The crude product so obtained is then purified by chromatography over silica gel (petroleum ether/dichloromethane gradient). The title product is obtained in the form of a powder.

1. additionThen the reaction mixture is poured onto water
2. extractionextracted with ether
3. dry with materialThe organic phase is subsequently dried over magnesium sulphate
4. filtrationfiltered
5. customevaporated to dryness
6. customThe crude product so obtained
7. customis then purified by chromatography over silica gel (petroleum ether/dichloromethane gradient)