N-methyl-2-pyrrolidone → HCID 117974290, compound

Participants

Reaction Steps

41 mg of sodium hydride (60% oil-based) was suspended into 4 ml of 1-methyl-2-pyrrolidone (NMP), and 0.13 g of 2-ethylthioimidazol was added under ice cooling. After stirring the mixture for 10 minutes, 0.2 g of 2-chloro-3-methyl-6-trifluoromethyl-3H-imidazo[4,5,b]pyridine was added, and the mixture was stirred under room temperature for 3 hours. Water was poured, and the deposited precipitate was obtained by filtration and was applied to a silica gel column chromatography to obtain 0.28 g of 2-(2-ethylthio-3H-imidazol-3-yl)-3-methyl-6-trifluoromethyl-3H-imidazo[4,5,b]pyridine (Compound of Present Invention (1)).

Provenance & Evidence