Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | N2-Methyl-5-(trifluoromethyl)pyridine-2,3-diamine | HCID 2735930 | — |
| Reactant | HCID 117974284 | HCID 117974284 | — |
| Catalyst | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 72203603 | HCID 72203603 | 116.2% |
Reaction Steps
A mixture of 0.12 g of N2-methyl-5-trifluoromethylpyridine-2,3-diamine, 0.2 g of 3-ethylthio-5-trifluoromethylthiophene-2-carboxylic acid, 0.15 g of EDCI hydrochloride, 9 mg of HOBt and 3 ml of pyridine was stirred at 80° C. for 6 hours. Water was poured into the cooled reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and dried over anhydrous magnesium sulfate, then concentrated under reduced pressure and applied to a silica gel column chromatography to obtain 0.3 g of 2-(3-ethylthio-5-trifluoromethylthiophen-2-yl)-3-methyl-6-t rifluoromethyl-3H-imidazo[4,5,b]pyridine (Compound of Present Invention (5)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09120792B2 |
|---|
| Source dataset | uspto-grants-2015_09 |
|---|
| ORD ID | ord-c0847a3f44234fee88908b9960fac3db |
|---|
| Source note | uspto-grants-2015_09 |
|---|
