Sodium Thiosulfate → HCID 117974277, compound

Participants

Reaction Steps

0.08 g of 3-chloroperoxybenzoic acid (purity of 65% or more) was added to 3 ml of a solution of 0.07 g of 2-(2-ethylthio-5-trifluoromethylthiophen-3-yl)-3-methyl-6-pentafluoroethyl-3H-imidazo[4,5,b]pyridine in chloroform under ice cooling, and the mixture was stirred for 2 hours and at room temperature for 1 hour. A 10% aqueous sodium thiosulfate solution was poured into the reaction mixture, and the mixture was extracted with chloroform. The organic layer was washed with a saturated aqueous sodium bicarbonate solution, then dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The resulting residue was applied to a silica gel column chromatography to obtain 0.07 g of 2-(2-ethylsulfonyl-5-trifluoromethylthiophen-3-yl)-3-methyl-6-pentafluoroethyl-3H-imidazo[4,5,b]pyridine (Compound of Present Invention (10)).

Provenance & Evidence