Dimethylformamide → HCID 117974266, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 0.22 g of 2-(3-chlorothiophen-2-yl)-3-methyl-6-trifluoromethyl-3H-imidazo[4,5-b]pyridine, 0.23 g of 2-(3-bromothiophen-2-yl)-3-methyl-6-trifluoromethyl-3H-imidazo[4,5-b]pyridine, 0.21 g of ethyl mercaptan sodium salt (80%) and 4 ml of DMF was stirred at 100° C. for 30 minutes. Water was poured into the reaction mixture, and the mixture was extracted with ethyl acetate. The combined organic layers were dried over anhydrous sodium sulfate and then concentrated under reduced pressure. The resulting residue was applied to a silica gel column chromatography to obtain 0.41 g of 2-(3-ethylthiothiophen-2-yl)-3-methyl-6-trifluoromethyl-3H-imidazo[4,5-b]pyridine (Compound of Present Invention (15)).

Provenance & Evidence