Sodium Thiosulfate → HCID 117974288, compound

Participants

Reaction Steps

0.25 g of 3-chloroperoxybenzoic acid (69 to 75%) was added to a mixture of 0.25 g of 2-(3-ethylthiothiophen-2-yl)-3-methyl-6-trifluoromethyl-3H-imidazo[4,5-b]pyridine and 5 ml of chloroform, under ice cooling, then the mixture was heated to room temperature and stirred for 1 hour. A saturated aqueous sodium bicarbonate solution and a saturated aqueous sodium thiosulfate solution were poured to the reaction mixture, and the mixture was extracted twice with ethyl acetate. The combined organic layers were dried over anhydrous sodium sulfate and then concentrated under reduced pressure. The resulting residue was applied to a silica gel column chromatography to obtain 0.10 g of 2-(3-ethylsulfinylthiophen-2-yl)-3-methyl-6-trifluoromethyl-3H-imidazo[4,5-b]pyridine (Compound of Present Invention (16)) and 0.12 g of 2-(3-ethylsulfonylthiophen-2-yl)-3-methyl-6-trifluoromethyl-3H-imidazo[4,5-b]pyridine (Compound of Present Invention (17)).

Provenance & Evidence