Sodium Thiosulfate → HCID 117974257, compound

Participants

Reaction Steps

0.81 g of 3-chloroperoxybenzoic acid (purity of 65% or more) was added to a mixture of 0.56 g of 2-(5-ethylthiothiazol-4-yl)-3-methyl-6-trifluoromethyl-3H-imidazo[4,5-b]pyridine and 10 ml of chloroform, under ice cooling, and the mixture was stirred at room temperature for 5 hours and then allowed to stand overnight. A 10% aqueous sodium thiosulfate solution was poured into the reaction mixture, and the mixture was extracted with chloroform. The organic layer was washed with a saturated aqueous sodium bicarbonate solution and dried over anhydrous magnesium sulfate, then concentrated under reduced pressure to obtain 0.6 g of 2-(5-ethylsulfonylthiazol-4-yl)-3-methyl-6-trifluoromethyl-3H-imidazo[4,5-b]pyridine (Compound of Present Invention (22)).

Provenance & Evidence