Sodium Thiosulfate → HCID 117974507, compound

Participants

Reaction Steps

0.5 g of 3-chloroperoxybenzoic acid (purity of 65% or more) was added to a mixture of 0.32 g of 2-(2-ethylthiopyrrol-1-yl)-3-methyl-6-trifluoromethyl-3H-imidazo[4,5-b]pyridine and 8 ml of chloroform, under ice cooling, and the mixture was stirred at room temperature for 3 hours and then allowed to stand overnight at room temperature. A 10% aqueous sodium thiosulfate solution was poured to the reaction mixture, and the mixture was extracted with chloroform. The organic layer was washed with a saturated aqueous sodium bicarbonate solution and dried over anhydrous magnesium sulfate, then concentrated under reduced pressure. The resulting residue was applied to a silica gel column chromatography to obtain 0.33 g of 2-(2-ethylsulfonylpyrrol-1-yl)-3-methyl-6-trifluoromethyl-3H-imidazo[4,5-b]pyridine (Compound of Present Invention (24)).

Provenance & Evidence